Fig. 5: Schematic models for sRNA-mediated degradation of mRNAs during transcription and translation. | Nature Communications

Fig. 5: Schematic models for sRNA-mediated degradation of mRNAs during transcription and translation.

From: Structure of the 30S translation initiation complex coupled to paused RNA polymerase and its potential for riboregulation

Fig. 5

Four modes are presented where the RNA degradosome could access transcripts tagged with sRNAs. A Access to the mature mRNA after transcription termination. B Access at early stages of translation explored in this study. Mode (i) depicts a scenario in which the degradosome can access the coding region following the formation of the pioneering 30S IC. Mode (ii) posits access to the translation initiation complex in the vicinity of the paused transcription elongation complex. C Access for co-translation degradation. Here, the degradosome could be interacting with polysomes once the mRNA has begun to be translated. This mode is supported by the in vivo observation of RNA cluster formation by degradosomes in the presence of polysomes (Hamouche et al. 2021).

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