Fig. 6: Presence of an immunosuppressive and angiogenic neutrophil subset.
From: Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma
Boxplots for A Arginase 1 (ARG1) and B S100 Calcium Binding Protein A7 (S100A7) showing the normalized intensity across all clusters. Uniform manifold approximation and projection (UMAPs) for C Extracellular Matrix Protein 1 (ECM1), D S100 Calcium Binding Protein A10 (S100A10), E Matrix Metallopeptidase 9 (MMP9) and F Matrix Metallopeptidase 8 (MMP8). Dotplots showing G core lysosomal proteins and the H 20S  proteasome proteins. I UMAP for the ubiquitin protein (RPS27A). Dotplot showing J immunoglobulin proteins and K Desmosome related proteins. For all UMAPs (n = 277) the colour scale shows the log normalized protein abundance. Armed (n = 76), Engaged (n = 46), Vital NETs (n = 33), Exhausted (n = 47), Lytic NETs (n = 32), Immunosuppressive and angiogenic (n = 23) and Vascular Immature (n = 22). For all boxplots the top and bottom hinges represent the 1st and 3rd quartiles. The top whisker extends from the hinge to the largest value no further than 1.5× interquartile range (IQR) from the hinge; the bottom whisker extends from the hinge to the smallest value at most 1.5× IQR of the hinge. For panels (A, B) the individual protein boxplot adjusted p-values were calculated using Seurat with logistic regression and are two-sided.
