Fig. 6: Comparison of dsRNA recognition by secreted antibodies versus intracellular proteins.
From: Structural basis of double-stranded RNA recognition by the J2 monoclonal antibody
a Overall structures of J2 and S9.6 antibodies bound to dsRNA and RNA-DNA hybrid, respectively, and dsRNA-bound structures with ADAR2, SID1, RIG-I, MDA5, OAS1, and TLR3. b Comparison of the minor groove tracking strategy employed by J2 and S9.6 with the helical axis tracking, ridge-spanning strategy used by ADAR2 and SID1.
