Fig. 7: Graphical abstract. | Nature Communications

Fig. 7: Graphical abstract.

From: G-CSF/NAMPT signaling drives neutrophil dysfunction and enhances bacterial infection susceptibility in cancer patients

Fig. 7: Graphical abstract.

Chronic tumor-derived G-CSF–NAMPT signaling reprograms neutrophil progenitors, drives accumulation of tissue-toxic, infection-permissive neutrophils and is associated with persistence of Gram-negative pathogens and worse outcome in cancer. G-CSF granulocyte colony-stimulating factor, NAMPT nicotinamide phosphoribosyltransferase, NAD+ nicotinamide adenine dinucleotide.

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