Fig. 1: Proteomic partitioning and growth relations across E. coli’s cellular compartments.
From: Maintenance of cytoplasmic and membrane densities shapes cellular geometry in Escherichia coli
a E. coli’s three distinct, spatially separated compartments—the cytoplasm (gray), membranes (blue), and intermembrane space termed the periplasm (purple). The proteome is partitioned between these compartments. The mass fraction of the total proteome occupied by b the cytoplasm ψcyto, c the periplasm ψperi, and d inner and outer membranes ψmem as a function of the steady-state growth rate. Dashed lines represent empirical linear regressions on the data, with slopes as follows: ψcyto → ≈ 0.05 h; ψperi → ≈ −0.04 h; ψmem → ≈ − 0.004 h. e The linear trade-off correlation between the proteome allocation toward the cytoplasm and periplasm with a slope of ≈ − 1. f The sum total proteome mass fraction of the cytoplasm and periplasm ψcyto + ψperi as a function of the growth rate. Dashed line is a linear regression on the data with a slope of ≈ 0.004 h. See Supplementary Table 1 for values of slopes, intercepts, and their normalized values. See also Supplementary Fig. 4 for a comparative analysis of proteome partitioning across literature datasets.
