Fig. 5: Percent change contrasting first-vaccinated group minus first-infected group in four pairs of sequences of previous exposures for IgA and IgG against RBD at T10 and T11*.

* Estimates from linear mixed models estimating the %MFI increase in different exposure histories. The models accounted for repeated measurements in the same individual with a random intercept per individual. The model was adjusted adapting the main model (M5), i.e., excluding the number of previous infections and vaccines and using the history per se: age (restricted cubic spline with 3 df) + sex + number of chronic comorbidities and tobacco smoking status + days from last infection (restricted cubic spline with 3 df) + days from last vaccine (restricted cubic spline with 3 df) and a factor with the history of the most common combinations. For each model, there were 337 samples from T10 and 309 samples from T11, totaling 646 samples from 357 individuals. The central circles represent the point estimates, and the vertical bars indicate the 95% confidence intervals corrected by multiple comparisons with the Bonferroni method. Green color represents confidence intervals that do not include zero. The symbols represent the contrasts that achieved the statistical threshold of p ≤ 0.05 accordingly with multiplicity correction methods: *p ≤ 0.05 without any correction; ^†p ≤ 0.05 with false-discovery rate (FDR) correction, and ●p ≤ 0.05 with Bonferroni correction. All p-values analysed in Fig. 5 can be seen at Supplementary eFig. 4. Source data are provided in the source data. df: degrees of freedom. MFI: median fluorescence intensity. M: model. T: timepoint. RBD: Receptor binding domain.