Fig. 6: Longitudinal Wuhan antibody levels against N, RBD, and S proteins over time. | Nature Communications

Fig. 6: Longitudinal Wuhan antibody levels against N, RBD, and S proteins over time.

From: Primary SARS-CoV-2 exposure by vaccination or infection shapes immune responses to omicron variants among a Spanish cohort

Fig. 6: Longitudinal Wuhan antibody levels against N, RBD, and S proteins over time.

The blue and red solid lines represent the first-vaccinated and first-infected fitted curves calculated using the LOWESS (locally estimated scatterplot smoothing, ggplot2::geom_smooth) method with the following parameters: degree: “2 - quadratic”; family: “gaussian”; surface: “interpolate”, span 0.50. The dashed gray lines represent the mean cutoff values for each antibody and isotype to be considered positive. We used the mean cutoff across the timepoints to provide a single line in the figure. Cutoff values: For IgA, the mean cutoff values were 2018.49 (SD = 530.17) for the N, 441.30 (SD = 136.65) for RBD, and 421.53 (SD = 60.68) for S. For IgG, the mean cutoff values were 28128.12 (SD = 9968.65) for N, 103.33 (SD = 28.58) for RBD, and 246.40 (SD = 99.78) for S. Shaded areas represent 95% confidence intervals. Source data are provided in the source data. MFI: median fluorescence intensity. N: nucleocapsid. RBD: receptor binding domain. S: Spike.

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