Fig. 7: Magnitude of T-cell responses at T11 by first exposure groups and correlations with antibody responses. | Nature Communications

Fig. 7: Magnitude of T-cell responses at T11 by first exposure groups and correlations with antibody responses.

From: Primary SARS-CoV-2 exposure by vaccination or infection shapes immune responses to omicron variants among a Spanish cohort

Fig. 7

A Boxplots representing T-cell responses as SFUs / 106 peripheral blood mononuclear cells (PBMCs) secreting IFN-γ, IL-2 or IFN-γ + IL-2 (polyfunctional) to S or N + M from Wuhan by first exposure groups. Responses were compared by Wilcoxon Signed-Rank test. Boxplots represent median (bold line), the mean (black diamond), 1st and 3rd quartiles (box), and largest and smallest values within 1.5 times the interquartile range (whiskers). B Heatmaps illustrating the Spearman’s correlation coefficient ρ (Rho) between the SFU / 106 PBMCs of T-cells secreting IFN-γ, IL-2 or IFN-γ + IL-2 (polyfunctional) to S and N + M with the antibody responses (median fluorescence intensity (MFI) of IgA and IgG). p-values: * ≤ 0.05, ** ≤ 0.01. IFN-γ: Interferon-gamma. IL-2: Interleukin-2. M: Membrane. N: Nucleocapsid. RBD: Receptor binding domain, S: Spike. SFU: Spot-forming units. First-infected (N = 21), First-vaccinated (N = 28). P-values in both Panel A and B are from two-sided tests. Source data are provided in the source data. Note: T-cell findings may be underpowered because of limited sample size.

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