Table 1 Characteristics of cohort stratified by the first exposure being an infection or vaccination
First-infected (n = 197) | First-vaccinated (n = 160) | p-valuea | |
|---|---|---|---|
Timepoint (%) | 0.813 | ||
T10 | 28 (14.2) | 20 (12.5) | |
T10 and T11 | 159 (80.7) | 130 (81.2) | |
T11 | 10 (5.1) | 10 (6.2) | |
Age, mean (SD), years | 50.2 (11) | 47.1 (10) | 0.006 |
Female, n (%) | 165 (83.8) | 138 (86.2) | 0.613 |
Number of chronic comorbidities | |||
mean (SD) | 0.78 (1.01) | 0.46 (0.73) | |
median [IQR] | 0 [0, 1] | 0 [0, 1] | 0.002 |
Chronic respiratory disease, n (%)b | 8 (4.1) | 12 (7.5) | 0.24 |
COPD, n (%) | 0 (0.0) | 3 (1.9) | 0.178 |
Asthma, n (%) | 8 (4.1) | 10 (6.2) | 0.486 |
Tobacco smoking status, n (%) | <0.001 | ||
No | 137 (69.5) | 92 (57.5) | |
Previous smoker | 49 (24.9) | 38 (23.8) | |
Active smoker | 11 (5.6) | 30 (18.8) | |
Cardio-metabolic, n (%)b | 31 (15.7) | 11 (6.9) | 0.016 |
Dyslipidemia, n (%) | 14 (7.1) | 4 (2.5) | 0.083 |
Hypertension, n (%) | 13 (6.6) | 6 (3.8) | 0.339 |
Diabetes, n (%) | 7 (3.6) | 0 (0.0) | 0.043 |
Cardiovascular diseases, n (%) | 2 (1.0) | 2 (1.2) | >0.99 |
Obesity, n (%) | 23 (11.7) | 9 (5.6) | 0.071 |
Neurologic, n (%) | 2 (1.0) | 2 (1.2) | >0.99 |
Gastrointestinal, n (%) | 9 (4.6) | 4 (2.5) | 0.451 |
Chronic renal disease, n (%) | 0 (0.0) | 1 (0.6) | 0.917 |
Immunosuppressed status, n (%)b | 20 (10.2) | 8 (5.0) | 0.109 |
Autoimmune disease, n (%) | 13 (6.6) | 6 (3.8) | 0.339 |
Cancer, n (%) | 6 (3.0) | 2 (1.2) | 0.435 |
Other immunosuppression, n (%) | 2 (1.0) | 0 (0.0) | 0.572 |
Hypothyroidism, n (%) | 17 (8.6) | 10 (6.2) | 0.519 |
Depression, n (%) | 5 (2.5) | 2 (1.2) | 0.625 |
Pregnancy, n (%) | 3 (1.5) | 1 (0.6) | 0.767 |
History of allergy, n (%) | 33 (16.8) | 13 (8.1) | 0.024 |
