Fig. 5: High functional connectivity and clinical relevance of myoblast fusion screen hits. | Nature Communications

Fig. 5: High functional connectivity and clinical relevance of myoblast fusion screen hits.

From: Development of a split-toxin CRISPR screening platform to systematically identify regulators of human myoblast fusion

Fig. 5: High functional connectivity and clinical relevance of myoblast fusion screen hits.

STRING analysis identified 1286 protein-protein interactions (PPI, shown as connecting lines) among 160 myoblast fusion screen hits (represented as circles). These proteins form 23 distinct complexes, each highlighted in a different color. Red and green circles denote knockouts that decreased or increased myoblast fitness, respectively, in our myoblast fitness screen. Gene names in blue indicate factors previously known to regulate myogenesis.

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