Fig. 1: Overview of the ec3D workflow.
From: Reconstructing the three-dimensional architecture of extrachromosomal DNA with ec3D
Ec3D takes the amplicon sequence coordinates and chromatin capture (Hi-C) data as input, and outputs the 3-dimensional coordinates of each fixed-resolution bin. It also resolves the structure of duplicated regions within ecDNA. Finally, it computes and reports significant interactions between pairs of bins.
