Fig. 4: Comparison of the active-state structures of Gq-coupled ADGRL4, ADGRL3, ADGRE5 and ADGRF1. | Nature Communications

Fig. 4: Comparison of the active-state structures of Gq-coupled ADGRL4, ADGRL3, ADGRE5 and ADGRF1.

From: Structure of the Gq-coupled adhesion receptor ADGRL4

Fig. 4: Comparison of the active-state structures of Gq-coupled ADGRL4, ADGRL3, ADGRE5 and ADGRF1.The alternative text for this image may have been generated using AI.

a Structural superposition of ADGRL4 (purple), ADGRL3 (yellow), ADGRE5 (orange) and ADGRF1 (green). b Diversity of loop structures between receptors; the coloration is the same as in (a). c Comparison of the amino acid contacts (distance cut-off ≤3.9 Å) made by the tethered agonist and receptor within the orthosteric binding pocket for ADGRL4, ADGRL3, ADGRE5 and ADGRF1 coupled to Gq: bold, those residues making contacts to the helical region; italics, those residues making contacts to the bend; green, hydrophobic residues; blue, positively charged residues; red, negatively charged residues; yellow, polar uncharged residues. PDB IDs: ADGRL3, 7wy5; ADGRE5, 7ydm; and ADGRF1, 7wxu.

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