Fig. 3: Ligand binding pocket of CysLT2R.
From: Molecular insights into ago-allosteric modulation at cysteinyl leukotriene receptor 2
a The alignment of LTC4- and LTD4- bound CysLT2R structures. Details of key residues of the binding pockets are highlighted for LTC4 (b) and LTD4 (c). Hydrogen-bond interactions are highlighted as red dashed lines. Right panels: concentration–response curves of NanoBiT assay signals of WT and H1423.56A and R145ICL2A mutants following stimulation with LTC4 (b) or LTD4 (c). Data are shown as the mean ± s.e.m. from three independent measurements (n = 3). Source data are provided in the Source Data file. Effects of mutations of CysLT2R residues in the binding pocket on LTC4 (d) or LTD4 (e) potency. The pEC50 and Emax values are provided in Supplementary Table 2. Data are shown as the mean ± s.e.m. from three independent measurements (n = 3). Source data are provided in the Source Data file.
