Fig. 4: Comparison of CysLT2R structures in different states.
From: Molecular insights into ago-allosteric modulation at cysteinyl leukotriene receptor 2
a, b Structure alignment of LTC4 and C16:0 ceramide (PDB ID: 9JH5) activated CysLT2R. a Side view; b Left: extracellular view; right: intracellular view. c Comparison of the structures of CysLT2R bound with LTC4, C16:0 ceramide (PDB ID: 9JH5) and 11a (PDB ID: 6RZ6) at residues Y1193.33, Y1233.37, Y2636.51, H2646.52 and the “toggle switch” F2606.48. Hydrogen bonds are shown as red dashed lines. Data are shown as the mean ± s.e.m. from three independent measurements (n = 3). Source data are provided in the Source Data file. d The structural comparison of extracellular and intracellular parts of LTC4- bound with LTD4-, ceramide- (PDB ID: 9JH5), 11c- (PDB ID: 6RZ8) and 11a- (PDB ID: 6RZ6) bound CysLT2R structures. RMSD are presented. The hallmark conformational changes of TM6 and TM7 are marked with red arrows.
