Fig. 6: The Gq engagement of CysLT2R.
From: Molecular insights into ago-allosteric modulation at cysteinyl leukotriene receptor 2
a Structural superposition of LTC4-bound with ceramide-bound CysLT2R-Gq complex when CysLT2R was aligned. b, d, e Detailed interactions between CysLT2R and Gq. The α5 of Gαq is engaged through polar (b) and hydrophobic interactions (d) by CysLT2R, respectively. Interactions between the ICL2 of CysLT2R (e) and Gq shows common and distinct features. Polar interactions are marked with red dashed lines. c Representative concentration dependent response curves of mutations in the receptor-Gq interface in response to agonist. Data from three independent experiments are presented as the mean ± s.e.m. (n = 3). Source data are provided in the Source Data file. f ICL2 structure is stabilized by intra-ICL2 polar interactions upon CysLT2R-Gq coupling. Hydrogen bonds are marked with red dashed lines.
