Fig. 6: Pathological indicators of in vivo treatment.
From: In vivo chemogenetic RNA editing of macrophages by bioengineered viruses for sepsis treatment
a Total peritoneal protein in peritoneal of each surviving mouse treated by CLP. b Total peritoneal leukocytes in peritoneal of each surviving mouse treated by CLP. c, e, g Proinflammatory cytokines TNF-α, IL-1β and IL-6 level in serum of each surviving mouse treated by CLP. d, f, h Proinflammatory cytokines TNF-α, IL-1β and IL-6 level in peritoneal of each surviving mouse treated by CLP. i M2 polarization ratio of macrophages in the peritoneal cavity. Data shown in this figure are representative of three independent experiments. j Representative H&E of lung of animals after the indicated treatment. The black arrowheads indicate the infiltration of immune cells. The scale bar is 100 μm. Data represent means ± SD; n = 4 biologically independent samples in (a–h). One-way ANOVA with a Tukey post hoc test was used in a-h, NS denotes no significant difference (P > 0.05).
