Fig. 5: AcM-DDS suppresses inflammatory cytokines in IMQ-induced PO mice. | Nature Communications

Fig. 5: AcM-DDS suppresses inflammatory cytokines in IMQ-induced PO mice.

From: Antibody-conjugated mesenchymal stromal cell drug delivery system for the treatment of autoimmune diseases in mice

Fig. 5: AcM-DDS suppresses inflammatory cytokines in IMQ-induced PO mice.The alternative text for this image may have been generated using AI.

a Representative IF images of IL-21 in dorsal skin cryosections. Scale bars, 50 μm. b Quantification of IL-21 fluorescence intensity. n = 3 mice per group. c Representative IF images of IL-22 in dorsal skin cryosections. Scale bars, 50 μm. d Quantification of IL-22 fluorescence intensity. n = 3 mice per group. e Heatmap of 22 inflammatory cytokines in dorsal skin, analyzed via Luminex assay. n = 5 mice per group. Luminex-based quantification of IL-17A (f) and GM-CSF (g). h Representative H&E-stained images of spleen paraffin sections. Scale bars, 500 μm. i Quantification of splenic white pulp area. n = 12 fields per group. j Representative IHC images of IL-17A in spleen. Scale bars, 100 μm. k Quantification of IL-17A expression in spleens. n = 9 per group with 4 mice and two independent experiments. Data are presented as means ± SD and are analyzed by one-way ANOVA followed by Tukey’s multiple comparisons test (b, d, f, g, i, k). ns = no significance. Source data are provided as Source Data file.

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