Fig. 6: Therapeutic evaluation of AcM-DDS in a CIA mouse model of RA. | Nature Communications

Fig. 6: Therapeutic evaluation of AcM-DDS in a CIA mouse model of RA.

From: Antibody-conjugated mesenchymal stromal cell drug delivery system for the treatment of autoimmune diseases in mice

Fig. 6: Therapeutic evaluation of AcM-DDS in a CIA mouse model of RA.The alternative text for this image may have been generated using AI.

a Schematic of CIA induction, treatment regimen, and experimental timeline. Six to seven-weeks-old, 36 male DBA/1J mice (n = 6 mice per group) were used. Created in BioRender. Li, J. (2026) https://BioRender.com/rmjk4bf. b Arthritis incidence over time in each group. c Representative images of hind limb swelling at the study endpoint (Ⅰ), and Micro-CT 3D reconstructions of knee and ankle joints: Ⅱ, foot and ankle; Ⅲ, toes; Ⅳ, knee; Ⅴ, subchondral bone sections. d 3D heatmaps of subchondral bone microarchitecture: Tb.N, SMI and BV/TV. e Quantification of BV/TV. n = 3 mice per group. Toluidine staining of decalcified knee joint sections (f) and corresponding histological scores (g). n = 3 mice per group. Scale bars, 200 μm or 50 μm. Safranin O-Fast green staining of decalcified ankle joint sections (h) and scoring (i) for cartilage integrity. n = 3 mice per group. Scale bars, 500 μm (overview) or 100 μm (magnified view). Data are presented as means ± SD and are analyzed by one-way ANOVA followed by Tukey’s multiple comparisons test (e, g, i). ns no significance. Source data are provided as Source Data file.

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