Fig. 4: The CDE membrane globe and sodium ion binding site. | Nature Communications

Fig. 4: The CDE membrane globe and sodium ion binding site.

From: Structure of the Methanosarcina mazei Mtr complex bound to the oxygen-stress responsive small protein MtrI

Fig. 4

A Overview of a single CDE trimer in the Mtr complex. B CDE trimer (cartoon) with helices labelled. Top-down view from the cytosolic side towards the membrane. The sodium ion is shown as a purple sphere. C Side view of MtrE (cartoon). Membrane-embedded loop-helix-loop structure highlighted in light blue. The sodium ion is shown as a purple sphere. D Close-up view of the sodium ion binding site within MtrE. Selected residues shown as sticks together with their cryo-EM density (threshold: 0.116). D183, E60 and S28 together with three water molecules form an octahedral coordination complex around a sodium ion (purple sphere). A previously proposed second sodium ion has been reassigned as a water H2OD.

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