Fig. 1: Diet-driven gut microbial signatures and phenotypic correlates in ASD.
From: Distinct diet-microbiome associations in autism spectrum disorder
A Study design overview. Schematic representation of the analytical framework integrating dietary profiling, microbial compositions, and phenotypic characterization. The images were created by Y.Wu without third-party resources involved. B Microbial community alterations in gut microbial dysbiosis and microbial diversity score between children with and without ASD. Statistical significance was assessed using a two-tailed Mann-Whitney U-test comparison. C The effect size of diet and other confounders on the variability of the gut microbiome community is examined. The proportion of gut microbial variation explained by various phenotype factors was assessed using PERMANOVA. Bray-Curtis distance matrices, based on the relative abundances of microbial species, were analyzed using the adonis function in the R package vegan with 9999 permutations. D The associations between a healthy dietary pattern (CCDI) and gut microbial features vary between children with and without ASD. 95% confidence interval shown as a shaded in the scatter plot.
