Fig. 1: Cryo-EM structures of the classical and lectin pathway proconvertase, C4b2.
From: Structural insights into C3 convertase activity of the classical pathway of complement
a Cryo-EM density map at 3.5 Å overall resolution in two 180°-rotated orientations and cartoon-representation of the corresponding C4b2 structure. b Cryo-EM density map at 3.9 Å overall resolution obtained from a subset of particles and cartoon representation of the C4b2 model built in this map. Electron density maps are colored by local resolution from high (blue) to low (red), as indicated and models show C4b in blue, C2 CCP1-3 domains in purple and C2 VWA and SP domains in green.
