Fig. 5: Whole-genome doubling accelerates and reshapes aneuploidy evolution.
From: ALFA-K: Local adaptive mapping of karyotype fitness landscapes
a Passaging trajectories for p53 k.o. A (top) and p53 k.o. B (bottom): number of chromosomes differing from the euploid state plotted by passage number, colored by WGD status (WGD− = purple, WGD+ = green). Curves show fits from a non-linear saturation model accounting for additive effects of WGD status and trajectory on accumulation dynamics (see Supplementary Note 4.3). b ALFA-K–estimated relative fitness versus number of chromosomes altered: light-gray points are individual fitness estimates (n = 24,498 estimates derived from 2607 unique karyotypes pooled from the n = 2 independent biological lineages); red ticks denote mean within each missegregation bin. c Empirical cumulative distributions of one-MS-step fitness effects for frequently observed karyotypes in each lineage, comparing WGD− (purple) and WGD+ (green) subclones. Source data underlying these plots are available in the ALFA-K repository.
