Fig. 3: Comparison of genetic signals detected for 2157 proteins measured on both SomaScan and Olink Explore in 1889 MESA participants.
From: Cross-ancestry comparison of aptamer and antibody protein measures
A UpSet plot depicting total counts of proteins with cis- and trans-pQTL on each platform. Note that, as this is an inclusive UpSet plot, a given protein can be represented in more than one bar. B Table depicting the percentage of proteins associated with a platform-concordant, platform-discordant, SomaScan specific, or Olink specific cis-pQTL, which were also associated with a protein-altering variant (PAV). C Histogram of Pearson’s correlation coefficients (r values), with bars colored to indicate which proteins in the bin had a genome-wide significant cis-pQTL (p < 5 × 10−8) detected on SomaScan, Olink, both, or neither platform. D Table depicting the percentage of proteins associated with a pleiotropic trans-pQTL (signal significantly (p < 1 × 10−11) associated with ≥5 protein measures on a given platform, not necessarily the same proteins) among the proteins with a trans-pQTL on both platforms or one platform only. E Histogram of Pearson’s correlation coefficients (r values), with bars colored according to whether proteins in bin had a significant trans-pQTL detected on SomaScan, Olink, both, or neither platform. Source data is available in Supplementary Data 4, 5, 9, 10 (A), Supplementary Data 2, 4, 5 (B, C) and Supplementary Data 2, 9, 10 (D, E).
