Fig. 5: Adjustment for suPAR-associated, ancestry-differentiated PAV improves correlation of suPAR measures across all participants, with improvement driven by individuals of African ancestry.
From: Cross-ancestry comparison of aptamer and antibody protein measures
suPAR measures per platform, per-ancestry, without (A) and with (C) adjustment for PAV rs399145 (chr19:43665370:T:C; p.Thr86Ala) in 1852 unrelated participants with protein measures, whole genome sequencing data available, and ancestry group assigned (433 African ancestry (AFR), 220 Admixed American (AMR), 267 East Asian (EAS), and 932 European (EUR)). Violin plots show the full distribution of suPAR values by ancestry and platform; embedded box plots indicate the median (center line) and interquartile range (box). B SomaScan and Olink suPAR measures by genotype in 1889 participants with protein measures. Data are presented as the median protein levels (center line) with the 25th and 75th percentiles as box bounds; whiskers extend to 1.5× the interquartile range, and points beyond represent outliers. D suPAR pQTL summary statistics (generated under an additive model, two-sided test of significance) per platform and effect allele frequencies per ancestry group in MESA. cis-pQTL were significant at traditional genome-wide significance threshold (p < 5 × 10−8). Variant is most common in AFR ancestry group. E Inter-platform correlation of suPAR measures without and with PAV adjustment in 1889 participants. Values highlighted in red indicate which ancestry groups experienced the largest improvement in correlation following adjustment for PAV (here, AFR). Source data is available in Supplementary Data 4, 5 (D) and 6 (E). Source data for A, B, C is individual-level data available through dbGap and MESA.
