Fig. 2: Previously reported TREX1 SLE risk variants are not associated with SLE in UK Biobank. | Nature Communications

Fig. 2: Previously reported TREX1 SLE risk variants are not associated with SLE in UK Biobank.

From: Oligoprotein type I interferon signatures, but not TREX1 variants, increase risk of systemic lupus erythematosus in UK Biobank

Fig. 2: Previously reported TREX1 SLE risk variants are not associated with SLE in UK Biobank.The alternative text for this image may have been generated using AI.

A UpSet plot of sources of diagnosis for SLE in UK Biobank. B Carriers of TREX1 SLE risk variants by disease status in UK Biobank and an earlier genetic association study7. Numbers refer to carriers / total (%). C Clinical associations of previously reported TREX1 SLE risk variants7 in UK Biobank. Associations examined using logistic regressions with Firth penalisation adjusted for age, sex and the first ten genetic principal components (two-sided tests). Data are presented as adjusted OR (95% CI). aOR adjusted odds ratio, CI confidence interval, SLE systemic lupus erythematosus.

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