Fig. 5: Oligoprotein interferon signatures are associated with high risk of SLE in UKB-PPP, but are not elevated in TREX1 mutation carriers. | Nature Communications

Fig. 5: Oligoprotein interferon signatures are associated with high risk of SLE in UKB-PPP, but are not elevated in TREX1 mutation carriers.

From: Oligoprotein type I interferon signatures, but not TREX1 variants, increase risk of systemic lupus erythematosus in UK Biobank

Fig. 5: Oligoprotein interferon signatures are associated with high risk of SLE in UKB-PPP, but are not elevated in TREX1 mutation carriers.The alternative text for this image may have been generated using AI.

A A peripheral proteomic signature for type I interferon activation (MIRO score) predicts incident SLE (left) but not multiple sclerosis (right). Adjusted time-to-event curves by quartile of MIRO score from Cox regression models (HRs with 95% CIs, two-sided tests). B Density plot of MIRO score by TREX1 genotype. Association examined using a linear regression adjusted for age, sex and the first ten genetic principal components (two-sided test). C Density plot of MIRO score by LOFTEE classification. Associations examined using linear regressions adjusted for age, sex and the first ten genetic principal components (two-sided tests). D Scatter plot of MIRO score by CADD and LOFTEE classification. Associations examined using linear regressions adjusted for age, sex and the first ten genetic principal components (two-sided tests). CADD Combined Annotation-Dependent Depletion score (PHRED-like scaled), CI confidence interval, HR hazard ratio, pLOF high-confidence predicted loss-of-function from LOFTEE, MIRO Markers of type I Interferon Response in Olink.

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