Fig. 7: CBAF disruption enhances tumorigenesis without compromising the synovial sarcoma phenotype.

a Growth trajectories of mean tumor size (sample sizes indicated are biological replicates: individual tumors developing in individual mice; shading indicates ± standard deviations, p-values from two-tailed, heteroscedastic t tests, with individual p-values listed in Source Data file.) in hSS1 and b hSS2 mice injected with TATCre at day 8 of life comparing littermates with varied Arid1a-fl genotypes. c Similar tumor growth curves for hSS1 and d hSS2 for littermates with varied Arid1b-fl genotypes. e plots of nuclear shape ratios (closer to 1 indicates roundness) and density for tumors from the different genetic cohorts, with monophasic and poorly differentiated tumors across the spectrum in round dots and tumors with epithelial histomorphology indicated by triangles. f Example photomicrographs of tumors with retained SyS histomorphological features following varied Arid1 genotypes (An H&E stained section of each of the tumors produced was reviewed at the same sample size as the tumorigenesis experiments in a–d but representative photomicrographs were procured secondarily; each magnification bar is 10 µm). g Differential expression of SAT, h MAT, and i SST pattern genes comparing hSS2 tumors with wildtype versus homozygous floxed Arid1a genotypes. j Expression heatmap of bulk RNA-seq for SST pattern genes and k BAF component genes among hSS2 tumors with either Arid1a homozygous floxed, Arid1b homozygous floxed, or wildtype for both. Source data are provided as a Source Data file.