Table 1 Summary of the binding kinetics of anti-mCD27 antibodies

From: Harnessing multivalency and FcγRIIB engagement to augment anti-CD27 immunotherapy

Antibody

Ka (×106 M−1s−1)

Kd (×10−3 s−1)

Apparent affinity (KD, ×10−9 M)

Anti-mCD27 mIgG1

1.3

12.7

9.5

Anti-mCD27 mIgG1 NQ

1.1

14.4

13.1

Tetra anti-mCD27 mIgG1

1.6

2.9

1.8

Tetra anti-mCD27 mIgG1 NQ

1.6

2.4

1.5

  1. Kinetic fits for anti-mCD27 antibody binding were calculated using the Biacore kinetics summary v3.1 software and the bivalent (2:1) binding model fit to the data in Fig. 1C. Source data are provided as a Source data file.
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