Fig. 4: The Reelin signaling from LECs promoted tendon regeneration.

A The macrostructure of Achilles tendon in control and repair groups of Reln^fl/fl and Reln^cko mice. B The AFI in control and repair groups of Reln^fl/fl and Reln^cko mice. C HE and Masson’s trichrome staining in control and repair groups of Reln^fl/fl and Reln^cko mice. D The collagen content analysis in control and repair groups of Reln^fl/fl and Reln^cko mice. E, F The collagen amount and arrangement in control and repair groups of Reln^fl/fl and Reln^cko mice. G The microstructure of tendons and collagen fiber diameters quantification in the control and repair groups of Reln^fl/fl and Reln^cko mice, assessed by TEM and SEM. H Sagittal T2 MRI imaging and intensity in control and repair groups of Reln^fl/fl and Reln^cko mice. I, J The stress at failure and modulus in control and repair groups of Reln^fl/fl and Reln^cko mice. Red arrow: indicate the inflammation signal. Each dot represents one individual replicate (n = 5 biological replicates per group in B, D, F, H, I, J). Statistical significance was analyzed by One-way ANOVA with Tukey’s multiple comparisons test (B, D, F, H, I, J).