Fig. 3: Motif analysis results for experimental validation.
From: cfGWAS reveal genetic basis of cell-free DNA end motifs
A Box plot showing the MDS of cfDNA for plasma samples from wild-type (WT) and Panx1 KO mice. B and C Accumulated frequency of motifs showing significant positive and negative correlations, respectively, with SNPs in the PANX1 gene from GWAS analysis in plasma samples from WT and Panx1 KO mice. D Box plot of the MDS of cfDNA for cell culture supernatant from WT and PANX1 KO cell lines. E and F Accumulated frequency of motifs with significant positive and negative correlations, respectively, with SNPs in the PANX1 gene from GWAS analysis in cell culture supernatants from WT and PANX1 KO cell lines. These box plots are defined as follows: the center line represents the median, the box limits indicate the 25th and 75th percentiles, and the whiskers extend to the minimum and maximum values. Statistical significance, determined by a two-sided t-test, is indicated by asterisks with the following conventions: *p < 0.05, **p < 0.01, and ***p < 0.001. Created in BioRender. Su, S. (2025) https://BioRender.com/m1tkhdf.
