Fig. 1: Structure design and biocatalytic properties of HEA-based Janus artificial enzymes.

a Structure advantages of PtFeCuCoNi HEA NPs when compared with bare Pt NPs. b HEA-based Janus artificial enzymes with pH-gated redox biocatalysis. c Schematic illustration of sequential therapy of drug-resistant bacteria and inflammatory wounds by PtFeCuCoNi HEA NPs (VEC: vascular endothelial cells; M2: anti-inflammatory macrophages; RSF: Rat skin fibroblasts). Created in BioRender. Tian Chen (2025) https://BioRender.com/hs7ivcs.