Fig. 4: Scope of a-amino aldehydes, galactopyranose based and peptides related substrates.
From: Modular assembly of chiral amino acid derivatives and peptides from commonly available feedstocks
aReaction conditions: The reaction of 1 (0.25 mmol), 2 (0.1 mmol) and 3 (0.125 mmol) was carried out in MeCN (0.5 mL), DCM (1.0 mL) in the presence of TBADT (4.5 mol%), (R)-Na[5c] (20 mol%) under 40 W 390 nm LED light at −78 °C for 96 h. b7a was synthesized without CPA-Na at −30 °C. cWithout CPA-Na. dThe de was determined by 1H NMR while other products were determined by 1H NMR and HPLC. eReaction conditions: The reaction of 1 (0.25 mmol), 2a (0.1 mmol) and 3b (0.125 mmol) was carried out in MeCN (0.5 mL), DCM (1.0 mL) in the presence of TBADT (4.5 mol%), (R)-Na[5c] (20 mol%) under 40 W 390 nm LED light at −78 °C for 96 h. Ar1 4-bromo-3,5-dimethylphenyl, Boc tert-butyloxycarbonyl, Bn benzyl.
