Fig. 7: Scheme of degradation pathways for Gly-starting proteins. | Nature Communications

Fig. 7: Scheme of degradation pathways for Gly-starting proteins.

From: CUL4A-DDB1-DCAF10 is an N-recognin for N-terminally acetylated Src kinases

Fig. 7: Scheme of degradation pathways for Gly-starting proteins.

a Gly-starting proteins correctly modified by N-myristoylation (Myr) are stable and degraded via internal degrons when required for function. b Gly-starting proteins with alternative Nt-processing omitting N-myristoylation. Free glycine residues are recognized by CUL2-elonginB/C-ZYG11B/ZER1 (Gly/N-degron pathway), whereas proteins undergoing Nt-acetylation instead of N-myristoylation are targeted by the CUL4A-DDB1-DCAF10 (Ac-Gly/MO N-degron pathway). CBL Casitas B-lineage lymphoma protein; NMT N-myristoyltransferase 1 and 2; NatA Nt-acetyltransferase A. Created in BioRender. Bange, T. (2025) https://BioRender.com/tn5ptiw.

Back to article page