Fig. 4: B cells and plasma cells infiltrate the ocular compartment in JIA-uveitis patients. | Nature Communications

Fig. 4: B cells and plasma cells infiltrate the ocular compartment in JIA-uveitis patients.

From: Altered B cell activation contributes to the immunopathogenesis of childhood arthritis-associated uveitis

Fig. 4: B cells and plasma cells infiltrate the ocular compartment in JIA-uveitis patients.

A Bar chart showing the proportion of each U-MAP cluster as a proportion of total leucocytes infiltrating the AqH in n = 2 JIA-uveitis patients. B U-MAP showing the AqH infiltrating leucocytes in JIA-Uveitis patients (n = 2), a grey circle identifies the B cell cluster. Representative flow cytometry plots showing the frequency of CD19+ B cells expressing (C) CD27 and IgD, and (D) CD38 and CD20 within the AqH of n = 1 JIA-uveitis patient. E–G, H & E staining of historical whole enucleated JIA-uveitis eyes (n = 3, patients 1, 2 & 3). Light grey boxes indicate regions of interest, with magnified views shown in numbered images 1–3. Scale bars are displayed on each image. E Patient 1 showed plasma cell infiltration in the iris. F Patient 2 showed plasma cell infiltration in the iris and cornea. G Patient 3 showed plasma cell infiltration in the choroid. For each patient row, one whole eye section is shown, followed by an image showing numbered areas of plasma cell infiltration and example plasma cell images corresponding to highlighted areas. Black arrows indicate plasma cells identified based on morphology and confirmed by an expert histopathologist.

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