Fig. 5: EAU mice show features of peripheral antigen activation and heightened germinal centre reactions in the B cell compartment. | Nature Communications

Fig. 5: EAU mice show features of peripheral antigen activation and heightened germinal centre reactions in the B cell compartment.

From: Altered B cell activation contributes to the immunopathogenesis of childhood arthritis-associated uveitis

Fig. 5: EAU mice show features of peripheral antigen activation and heightened germinal centre reactions in the B cell compartment.

Data for (A–D) is generated from the spleen of naive mice (n = 16) and mice at D21 (n = 29) post EAU initiation. Representative flow cytometry plots (A) and dot plot (B) showing the frequency of CD95+GL7+ Germinal centre (GC) B cells within CD19+ live singlets. Representative flow cytometry plots (C) and dot plot (D) of CD138+Blimp-1+ plasmablasts within CD19+ live singlets. Representative flow cytometry plots (E) and (F) dot plot (F) showing the frequency of PD1+CXCR5+ T follicular helper (Tfh) T cells within CD4+ live singlets. The significance of the difference between all groups was determined using the two-tailed Mann-Whitney test. P-values below or equal to 0.05 are shown on graphs, and the significance threshold was set at ≤ 0.05. Error bars represent median ± IQR.

Back to article page