Fig. 6: B cells infiltrate the retinas of mice, specifically in those with severe uveitis. | Nature Communications

Fig. 6: B cells infiltrate the retinas of mice, specifically in those with severe uveitis.

From: Altered B cell activation contributes to the immunopathogenesis of childhood arthritis-associated uveitis

Fig. 6: B cells infiltrate the retinas of mice, specifically in those with severe uveitis.

Data were generated from the retina of naive mice (n = 16) and mice at D21 (n = 18) post EAU initiation. A Example fundus images of the adapted scoring system to create naïve (score 0), mild (score 1-2) and severe (score 3-5) disease phenotypes. Representative flow cytometry plots (B) and dot plot (C) of CD19+ B cells within CD45+ live singlets within the retina. (D) Dot plot showing the frequency of CD19+ B cells within CD45+ live singlets within the retina of naïve mice versus mice with mild and severe EAU. Significance of difference between groups in (C) was determined using the Mann-Whitney test. For (D), the significance of the difference between groups was determined using the Kruskal-Wallis test with Dunn’s post-hoc test for pairwise comparisons. P-values below or equal to 0.05 are shown on graphs, and the significance threshold was set at ≤ 0.05. Error bars represent median ± IQR.

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