Fig. 2: KC display of HRD and mutational signatures.
From: The Knowledge Connector decision support system for multiomics-based precision oncology
a Left, complex biomarkers, displayed via selection of the “Integrated Biomarkers” tab in the navigation bar, with numerical values for HRD, LSTs, and TAI to quantify genomic instability. Display frame on the right, visualization of total copy number (TCN), decrease of heterozygosity (DH), and B-allele frequency (BAF). b Visualization of exposures to mutational signatures as alternative content of the display frame; barplots display the exposures, whiskers indicate 95% confidence intervals as computed by profile likelihood. AC mutational signature, ALT alternative lengthening of telomeres, HLA human leukocyte antigen, HRD homologous recombination deficiency score, LST number of large-scale state transitions, TAI quantification of telomeric allelic imbalances, TMB tumor mutational burden.
