Fig. 9: HAPP@H-EXO promotes collagen sequential remodelling, vascularization, tendon regeneration, and stress redistribution. | Nature Communications

Fig. 9: HAPP@H-EXO promotes collagen sequential remodelling, vascularization, tendon regeneration, and stress redistribution.

From: Bionic Janus hydrogel drives infected Achilles tendon regeneration via mechano-immune spatiotemporal steering

Fig. 9: HAPP@H-EXO promotes collagen sequential remodelling, vascularization, tendon regeneration, and stress redistribution.

A Schematic illustration of the mechanism by which HAPP@H-EXO promotes collagen deposition, vascularization, and tendon cell regeneration. B Schematic of 2 w and 6 w specimens and staining. A: Achilles tendon. T: tibia. C: calcaneus. M: muscle. C Schematic of HE staining and magnification at 2 w and E 6 w. D The 2 w and F 6 w Masson staining plots, magnified images, and collagen orientation distribution based on Masson staining analysis. G Collagen orientation distribution scale. P Quantitative analysis of the collagen volume. H Sirius red staining at 6 w and Q quantitative analysis of the collagen I/III ratio. I CD31 immunofluorescence at 2 w and R quantitative analysis of the staining. J The 2 w and K 6 w SCX immunofluorescence and S quantitative analysis. L The 2 w and M 6 w TNMD immunofluorescence and T quantitative analysis. N The 2 w YAP immunofluorescence. O Schematic of stress homogenization and antiadhesion (n = 6, n values derived from different experimental units. The data are presented as the mean ± standard deviation. The statistical significance was determined by multiway ANOVA).

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