Fig. 3: Annual proportions of incident gonorrhoea infections with different antibiotic susceptibility statuses across various scenarios, 2024 to 2034.

Each (A–F) corresponds to a specific scenario, illustrating the changing annual proportions of four NG antibiotic susceptibility statuses among incident infections over the period shown. The stacked areas represent infections characterised by: neither Ceftriaxone DS nor HL TetR; Ceftriaxone DS only; HL TetR only; and both Ceftriaxone DS and HL TetR. Percentage labels on the left of each panel denote these respective proportions for 2024 (the year immediately preceding the 10-year intervention period), while labels on the right denote proportions for 2034 (the final year of the 10-year intervention period). All results shown are means derived from n = 900 independent simulations (30 stochastic simulations for each of the 30 best-fitting parameter sets). DS decreased susceptibility, HL TetR high-level tetracycline resistance (used as a proxy for doxycycline resistance), Doxy-PEP doxycycline post-exposure prophylaxis, STIs sexually transmitted infections, PrEP pre-exposure prophylaxis.