Fig. 7: The DEndo-UdECM/Tβ4@PLGA hydrogel restores fertility in a murine injury model. | Nature Communications

Fig. 7: The DEndo-UdECM/Tβ4@PLGA hydrogel restores fertility in a murine injury model.

From: Decidualization-empowered ECM hydrogel integrating sustained Tβ4 release drives endometrial regeneration in intrauterine adhesions

Fig. 7: The DEndo-UdECM/Tβ4@PLGA hydrogel restores fertility in a murine injury model.The alternative text for this image may have been generated using AI.

a Schematic of the fertility assessment timeline and experimental groups (Created in BioRender. Zhaowei, Y. (2025) https://BioRender.com/ul4iqzn). b Representative images of uterine horns showing embryo implantation sites (indicated by swelling) on Gestational Day 8 (GD8). The labels “Damage” and “PBS” denote the treated (right) and untreated control (left) uterine horns, respectively. c Representative images of live offspring born to treated female mice. d, e Quantification of implantation sites in the treated uterine horn (d) and the number of live offspring born per litter (e). f Representative images of weaned pups from all treatment groups that produced live offspring. Pups from all groups that produced live offspring showed 100% survival and normal development (see details in Table S2). In (d, e), data are presented as scatter dot plots from n = 6 biologically independent animals, with data shown as mean ± s.d. Statistical significance was determined by one-way ANOVA with Tukey’s post hoc test; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Detailed statistical analyses, including exact P values, test statistics (F values and degrees of freedom), and 95% confidence intervals, are provided in the Source Data file.

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