Table 3 Cost of oligonucleotides, phosphoramidite monomers, and triphosphate monomers for canonical and non-canonical nucleic acids
From: Advances and challenges in non-canonical nucleic acids data storage
Cost | Oligos (USD/100 nmole) | Phosphoramidites (USD/0.25 g) | Nucleoside triphosphate (USD/50 μmol) | |
|---|---|---|---|---|
Canonical nucleic acids | dA/T/G/C | 0.77 (10∼90 bases) | 8 | 122 |
rA/T/G/C | 8.7 (10∼60 bases) | 40 | 122 | |
Base modifications | 2-Amino-dA | 320 | 415 | / |
6m-dA | 223.94 | 580 | / | |
6m-rA | 447.88 | / | / | |
5m-dC | / | / | 969 | |
8-oxo dG | 285.01 | 975 | / | |
5-F-dU | / | 460 | 1318 | |
5-F-U | / | / | 1280 | |
5-Br-dU | 111.48 | 160 | / | |
Iso-dG/dC | 104.6 | 355 | / | |
Sugar modifications | 2′F | 41.84-55.88 | / | / |
TNA | / | 1875 | / | |
FANA | / | 295∼530 | 1700 | |
LNA | 21 | 85 | / | |
Backbone modification | Phosphorothioate Bond (PS) | 4.07 | / | 597 |
Mirror-image isomerism | L-DNA | / | 150 | / |
