Fig. 3: Outcome-specific progression stages and a unified prognostic staging system across the Alzheimer’s disease continuum. | Nature Communications

Fig. 3: Outcome-specific progression stages and a unified prognostic staging system across the Alzheimer’s disease continuum.

From: Biomarker-integrated prognostic stagings for Alzheimer’s Disease

Fig. 3: Outcome-specific progression stages and a unified prognostic staging system across the Alzheimer’s disease continuum.The alternative text for this image may have been generated using AI.

Unified prognostic staging system defined through the integration of outcome-specific stages. C1 and C2 are prognostic risk subgroups in the cognitively unimpaired (CU) group. M1 to M3 are prognostic risk subgroups in the mild cognitive impairment (MCI) group, while D1 and D2 are prognostic risk subgroups in the dementia group. Prognostic risk subgroups positioned at the same horizontal level represent equivalent stage. Stage labels (e.g., IVA, IVB) reflect clinical progression severity. Detailed methods are provided in Supplementary Method 3.

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