Fig. 1: Selective accumulation of CyMA at the Golgi through an enzyme switch to establish futile cycles.
From: Cycling molecular assemblies for Golgi imaging and disruption
a Schematic illustration of the futile cycle initiated by enzymatic deacylation of CyMA precursors, followed by selective accumulation at the Golgi through an enzyme switch involving thioesterases and palmitoyl acyltransferases. The consequences of CyMA accumulation at the Golgi in CES-/+ cells are illustrated. b Molecular structures and involved reaction pathways of CyMA precursors and metabolites within the futile cycle, along with exit from the cycle via hydrolysis of CyMA by esterases. c Molecular structures of CyMA (CyMA-i and CyMA-d) precursors, relevant analogs and control compounds.
