Fig. 1: LNPDB is a data repository and web tool for compiling and uploading LNP structure-function data. | Nature Communications

Fig. 1: LNPDB is a data repository and web tool for compiling and uploading LNP structure-function data.

From: Lipid Nanoparticle Database towards structure-function modeling and data-driven design for nucleic acid delivery

Fig. 1: LNPDB is a data repository and web tool for compiling and uploading LNP structure-function data.The alt text for this image may have been generated using AI.

a LNPDB compiles structural and functional data for 19,528 LNP formulations for nucleic acid delivery, representing 12,845 unique ionizable lipids across 42 publications and one commercial supplier (as of August 2025). LNPDB is available online (https://lnpdb.molcube.com) to view, search, and upload to the database. b Schematic illustration of a single LNP formulation encoded in LNPDB according to three general classes of features: composition (i.e., chemical type and ratio), experiment (i.e., methods and results), and simulation (i.e., CHARMM force field topology and parameter files for all-atom MD simulation). Example simulated bilayer for a single LNP formulation (LNP_0003871) composed of its constituent four components at specified ratios. c Snapshots from the LNPDB website demonstrating two ways to search the database: by properties (left; e.g., by specific library, composition properties, formulation properties, experimental properties) and by structures (right; e.g., by head, linker, tail, user-drawn structure).

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