Fig. 2: ExWAS Manhattan plots.
From: Rare coding variants in CHRNB3 associate with reduced daily cigarette smoking across ancestries
Manhattan plots showing results from exome-wide rare-variant association studies of cigarettes per day in the MCPS (a) and UKB (b). Number of individuals analyzed: MCPS – 37,897; UK Biobank – 133,133. Only aggregate level associations are plotted. The X axes correspond to chromosomal base pair start positions of individual genes and Y axes correspond to P values (expressed in negative log scale) from burden association tests performed using REGENIE. The dotted line corresponds to a statistical significance threshold of P = 2.6e-6. The direction of the triangle represents the direction of association (downward–cig per day decreasing; upward–cig per day increasing); MCPS Mexico City Prospective Study. Statistical test used: burden association test implemented in REGENIE software. Two-sided tests were performed with adjustment for multiple tests using Bonferroni method adjusting for the number of unique genes tested (n genes = 18,955).
