Fig. 3: Scope of perfluoroalkylarenes and polyfluorinated aliphatic amides for allylic fluoroalkylation. | Nature Communications

Fig. 3: Scope of perfluoroalkylarenes and polyfluorinated aliphatic amides for allylic fluoroalkylation.

From: Radical defluoroallylation of polyfluoroalkyl compounds with alkenes via synergistic photoredox/cobalt catalysis

Fig. 3: Scope of perfluoroalkylarenes and polyfluorinated aliphatic amides for allylic fluoroalkylation.

Reaction conditions: 1 (0.2 mmol), 2 (6 equiv.), fac-Ir(ppy)3 (0.5 mol%), methylcobalamin (3 mol%), HBpin (0.3 equiv.), and DIPEA (0.25 equiv.) in degassed 6 mL 2-ethoxyethanol, blue LEDs, 36 h, under nitrogen. a1 (0.2 mmol), 2 (6 equiv.), fac-Ir(ppy)3 (3 mol%), methylcobalamin (3 mol%), Cs2CO3 (1 equiv.) HBpin (2 equiv.) and DIPEA (3 equiv.) in degassed 6 mL DMF, 1 atm CO2 (headspace volume: 14 mL), blue LEDs, 36 h. All yields are isolated yields. All regioselectivity >20:1.

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