Fig. 1: Effects of stem cell infusion timing on GVHD incidence and survival in UCBT patients infused prior to 12 pm. | Nature Communications

Fig. 1: Effects of stem cell infusion timing on GVHD incidence and survival in UCBT patients infused prior to 12 pm.

From: Circadian fluctuation of soluble CD26 dictates the impact of the timing of cord blood transplantation on acute graft-versus-host disease

Fig. 1: Effects of stem cell infusion timing on GVHD incidence and survival in UCBT patients infused prior to 12 pm.

a Diagram of patients who underwent UCBT. Patients were divided into two groups on the basis of stem cell infusion timing, with a cutoff time of 9:40 am. UCBT, unrelated cord blood transplantation; CR, complete remission; MRD minimal residual disease; CB, cord blood. b Histogram showing the distribution of stem cell infusion times in the cohort. c, d Cumulative incidence (CI) of grade II-IV aGVHD (c) (P = 0.416) and grade III-IV aGVHD (d) (P = 0.004) in the earlier infusion (≤ 9:40 am, n = 219) and later infusion (> 9:40 am, n = 215) groups. The P values are two-sided and reported as exact values. e CI of overall chronic GVHD (cGVHD) in the earlier infusion (≤ 9:40 am) and later infusion (> 9:40 am) groups (P = 0.276). The P values are two-sided and reported as exact values. f CI of 3-year TRM in the earlier infusion (≤ 9:40 am, n = 219) and later infusion (> 9:40 am, n = 215) groups (P = 0.067). The P values are two-sided and reported as exact values. g–i Probabilities of overall survival (g) (P = 0.022), disease-free survival (h) (P = 0.050), and GRFS (i) (P < 0.001) in the earlier infusion (≤ 9:40 am, n = 219) and later infusion (> 9:40 am, n = 215) groups. j CI of 3-year relapse in the earlier infusion (≤ 9:40 am, n = 219) and later infusion (> 9:40 am, n = 215) groups (P = 0.775). The P values are two-sided and reported as exact values.The data were analyzed by Gray’s test (c–f, and j) and the log-rank test (g–i). Source data are provided as a Source Data file.

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