Fig. 2: Circadian variation of sCD26/DPPIV levels and their association with pretransplant immune milieu. | Nature Communications

Fig. 2: Circadian variation of sCD26/DPPIV levels and their association with pretransplant immune milieu.

From: Circadian fluctuation of soluble CD26 dictates the impact of the timing of cord blood transplantation on acute graft-versus-host disease

Fig. 2: Circadian variation of sCD26/DPPIV levels and their association with pretransplant immune milieu.

a Experimental design. Blood samples were collected at 7:00 am ± 15 min (n = 10) or 11:30 am ± 15 min (n = 10) from recipients with malignant hematological diseases in complete remission prior to cord blood infusion. b, c Serum concentrations of cytokines before cord blood infusion. Normalized z score (b) and absolute concentrations (c) of cytokines between 7:00 am and 11:30 am. The P values are two-sided and reported as exact values. d Absolute concentrations of soluble CD26/DPPIV in serum post-MAC. Blood samples were collected from recipients at 7:00 am ± 15 min (n = 19), 11:30 am ± 15 min (n = 19), or 4:00 pm ± 15 min (n = 29). e–i Associations between serum soluble CD26/DPPIV (sCD26/DPPIV) levels and inflammatory cytokines before cord blood infusion on day 0. Pearson’s correlation coefficient (r) was calculated for the relationships between serum DPPIV levels and IL-1Ra (e) (r = 0.476, P = 0.034), IL-1β (f) (r = 0.450, P = 0.046), LIF (g) (r = 0.517, P = 0.020), IL-18 (h) (r = −0.811, P < 0.001) and IL-1α (i) (r = 0.006, P = 0.741) concentrations. The P values are two-sided and reported as exact values.The data are presented as the means ± SEMs and were analyzed by unpaired t test followed by Bonferroni-Dunn correction (c), one-way ANOVA with Bonferroni multiple comparisons (d) and Pearson’s correlation (e–i). Source data are provided as a Source Data file.

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