Table 1 Multivariate analysis of factors associated with aGVHD, relapse and survival in UCBT patients infused prior to 12 pm (n = 434)

From: Circadian fluctuation of soluble CD26 dictates the impact of the timing of cord blood transplantation on acute graft-versus-host disease

Variable

Multivariate analysis

HR

95%CI

P

Grade II-IV acute GVHD

 Infused TNCs count

1.10

1.03–1.17

0.002

 HLA compatibility

1.38

1.08–1.78

0.012

Grade III-IV acute GVHD

 Infusion time

1.37

1.03–1.83

0.031

 Infused TNCs

1.12

1.04–1.20

0.002

 HLA compatibility

1.51

1.10–2.06

0.011

3-year TRM

 HLA compatibility

1.73

1.11–2.68

0.015

3-year Relapse

 ALL vs AML

2.69

1.53–4.72

<0.001

3-year OS

 HLA compatibility

1.45

1.07–1.97

0.016

 ALL vs AML

1.62

1.11–2.35

0.012

3-year DFS

 ALL vs AML

1.69

1.19–2.41

0.004

3-year GRFS

 Infusion time

1.36

1.11–1.66

0.003

  1. Multivariate analyses of aGVHD, TRM and relapse were performed via the Fine-Gray proportional hazards regression model, whereas OS, DFS, and GRFS were analyzed via the Cox proportional hazards regression model. The infusion times were included as ordinal data. Independent risk factors were identified via the stepwise selection method on the basis of the P value. All tests were two-sided, and exact P values are reported. No adjustment was made for multiple comparisons.
  2. GVHD graft-versus-host disease, TNCs total nucleated cells, HLA human leucocyte antigen, TRM transplant-related mortality, OS overall survival, DFS disease-free survival, GRFS GVHD-free, relapse-free survival.
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