Fig. 1: Identification of focal adhesion kinases as potential mediators of leptin action and TubA’s obesity reducing effect.
From: The focal adhesion kinases regulate leptin action and the weight reducing effect of HDAC6 inhibition
a Heat map of differentially regulated transcripts obtained by bulk RNA sequencing of the hypothalamic from the DIO wild-type mice treated with vehicle or TubA for four consecutive days (n = 3 Veh/TubA mice). b Connectivity Map (CMap) similarity scores of the perturbagens for the up- and down-regulated hypothalamic transcripts from TubA-treated mice used as query. Top 20 positively (left) and negatively (right) associated perturbagens are shown. c Heat maps of the differentially regulated genes from LepR+ cells obtained from lean wild-type mice after PBS or leptin treatment46. d CMap scores of the perturbagens and the top associations for the leptin gene expression signature from (c). Individual (e) and averaged-combined (f) CMap similarity scores of TubA and leptin plotted. Top two positively associated and top two negatively associated perturbagens are marked.
